Persea americana Mill.: As a potent quorum sensing inhibitor of Pseudomonas aeruginosa PAO1 virulence

The emergence of bacteria resistant to conventional antibiotics and the inability these treat bacterial biofilm-induced infections cause millions deaths every year. This situation has prompted scientists develop alternative strategies combat infectious diseases. Among these, researches on phytochemicals reduce virulence in Pseudomonas aeruginosa have gained momentum recent years. main reasons behind this are production factors biofilm formation, all which under control quorum sensing (QS) system. Hence, inhibition QS pathways is an eligible strategy for microbial pathogenesis. For first time present study, methanolic seed extract avocado was evaluated its anti-QS activity against P. PAO1. results experiments carried out proved that inhibitory regulation formation. Phytochemical analysis resulted identification epicatechin, catechin, chlorogenic acid, caffeic quercetin, kaempferol, vanillin, ferulic acid extract. Then, mechanism action investigated through molecular docking. Docking outcomes demonstrated major components, could bind receptors competitively. mode might be QS. Considering computational literature, it thought prepared from seeds may related synergistic effect contains.